C957T polymorphism of the dopamine D2 receptor (DRD2) gene affects striatal DRD2 availability in vivo
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چکیده
منابع مشابه
Depressive rumination and the C957T polymorphism of the DRD2 gene.
Depressed individuals who ruminate have difficulties learning from punishment and suppressing task-irrelevant information. The C957T polymorphism of the DRD2 gene, which affects functioning of D2 dopamine receptors (DRD2) that are expressed predominantly in the indirect pathway of the basal ganglia, has been found to influence suppression and punishment learning. Given these associations, we ex...
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We assessed the role of the DRD2 dopaminergic striatal gene polymorphism on performance in unidimensional and conjunctive rule-based category learning tasks. The unidimensional task requires a rule along a single stimulus dimension, while the conjunctive rule task utilizes a combination of two dimensions to distinguish members of each category. The results show that DRD2 C957T T allele carriers...
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A recent study showed an association between the dopamine D2 receptor gene (DRD2) and smoking. The purpose of this study was to determine if the familial transmission of smoking is linked to variation at the DRD2 locus in a genetically informative sample. Subjects were identified in alcohol treatment centers and their relatives were recruited for study. All subjects were interviewed to assess a...
متن کاملParental control and the dopamine D2 receptor gene (DRD2) interaction on emotional eating in adolescence.
The present study addresses the emergence of emotional eating in adolescence in relation to maternal or paternal psychological control. A reduction of food intake is considered the biological natural response to distress, therefore we tested whether the a-typical stress response of emotional eating develops in interaction with genetic vulnerability. Carrying the A1 allele of the dopamine D2 rec...
متن کاملDRD2 C957T polymorphism interacts with the COMT Val158Met polymorphism in human working memory ability.
The C957T polymorphism in the dopamine D2 receptor (DRD2) gene and the Val158Met polymorphism in the Catechol-O-Methyl-Transferase (COMT) gene affect dopamine transmission and have been found to be associated with schizophrenia. Since DRD2 in mice and the COMT gene in humans modulate working memory, we examined the relationship and possible interaction of both polymorphisms to working memory pe...
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ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2004
ISSN: 1359-4184,1476-5578
DOI: 10.1038/sj.mp.4001561